China’s CRISPR Babies

According to Chinese medical documents posted online this month (here and here), a team at the Southern University of Science and Technology, in Shenzhen, has been recruiting couples in an effort to create the first gene-edited babies. They planned to eliminate a gene called CCR5 in order to render the offspring resistant to HIV, smallpox, and cholera.
The clinical trial documents describe a study to employ CRISPR to modify human embryos, then to transfer them into the uterus of mothers and deliver healthy children.

It is unclear if any children have been born. The scientist behind the effort, Jiankui He, did not reply to a list of questions about whether the undertaking had produced a live birth. Reached by telephone he declined to comment. However, data submitted as part of the trial listing shows genetic tests have been carried out on fetuses as late as 24 weeks, or six months. It’s not known if those pregnancies were terminated, carried to term, or are ongoing.

The birth of the first genetically tailored humans would be a stunning medical achievement, for both He and for China. But it will prove controversial, too. Where some see a new form of medicine to eliminate genetic disease, others see a slippery slope to enhancements, designer babies, and a new form of eugenics. 

Source: MIT Technology Review

The Incredible Promise of CRISPR

Clustered regularly interspaced short palindromic repeats / Cas9, better known as just CRISPR, is a form of genetic modification that utilizes the immune system of bacteria to selectively remove or replace individual genes. As you can imagine, it is a very complex concept — I recommend this great full explainer – but it has vast implications for the future of human health and prosperity, Continue reading